Your Best Shot: The Personalized System for Optimal Weight Health—GLP-1 Shot or Not

The real revolution of the GLP-1 shots is the insight that the body regulates appetite and more with the hormones GLP-1, GIP, PYY, and CCK—and with Your Best Shot in hand, you can learn to optimize their function and your weight health for life.

Whether you have a little or a lot of fat to lose, cravings to curb, or use a shot or don’t, weight health hormone optimization is your best shot. Over two decades of research in her practice, renowned weight health expert Ashley Koff, RD, developed this game-changing system for patients and practitioners. Taking your best shot, you:

• determine whether your weight-health hormone function is suboptimal • identify your suboptimal-function type and narrow down causes • get specific, targeted, doable recommendations • use experiments to lock in on your better choices • develop strategies to tune out food noise and fight infobesity • learn how to vet the growing number of weight-health hormone-targeting medications, supplements, and devices • discover why better, not perfect, is the route to optimized health • choose the methods and tools you'll use to reset your course whenever life happens

This evidence-based program is for anyone pursuing weight health—the majority of us not using a weight health hormone replacement, along with the millions who are, or are ready to come off it.

Your Best Shot is not another plan. It’s your plan.

© 2026 HarperOne (Audiobook): 9780063444201

Release date

Audiobook: 6 January 2026