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Y Combinator

We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.

Head of Design Ryo Lu helped transform Cursor from a feature-layer on top of VS Code into one of the world's leading AI code editors.He joins YC's Aaron Epstein on Design Review to talk about the path that brought him to Cursor, how rapid prototyping reshaped the core product and how he's breaking down the barriers that once separated designers and coders.

The End of the Designer–Engineer Divide

In just a few years, James Hawkins took PostHog from an idea hacked together right before YC's W20 deadline to a unicorn powering product analytics for thousands of teams.

He joins YC's Brad Flora to talk about surviving six months of "pivot hell," why open-source analytics was the breakthrough, and how PostHog grew from fighting for its first users to launching full product lines—plus what he's learned about momentum, staying close to customers, and using transparency and humor to build a company that stands out.

From Pivot Hell To $1.4 Billion Unicorn

Every major shift in consumer tech has a moment when it suddenly becomes accessible to millions. Michael Mignano helped spark one of those moments with Anchor, making podcast creation something anyone could do with a tap. Now at Lightspeed, he sees AI bringing a similar leap to music, media, and everyday apps.In this conversation, he and Garry trace the arc from the early days of social audio to today's consumer AI boom—and dig into what founders should focus on as the next generation of creative tools takes shape.

The Best Consumer Startup Ideas Were "Impossible" Until Now

Cursor Head of Design Ryo Lu has spent his career at the intersection of design and engineering—from building fan sites as a kid to designing products at Stripe, Asana, and Notion. Now he's rethinking how software itself gets made.

On this episode of Design Review, Ryo joins YC's Aaron Epstein to break down how great product websites communicate what a company does. They walk through sites from early-stage startups, calling out the small choices in structure, clarity, and brand that help users understand a product instantly — and the ones that get in the way.

Cursor Head of Design Reviews Startup Websites

Starcloud recently made history by launching a satellite with an NVIDIA H100 into orbit — the first time a GPU that powerful has ever operated in space. It's the first step toward building AI data centers in orbit, powered by continuous sunlight and cooled by radiating heat into deep space.Their approach could one day rival the world's biggest data centers while using less energy, zero fresh water, and far lower emissions.In this episode of Hard Tech, YC's Aaron Epstein visits Starcloud's HQ, where co-founders Philip Johnston, Ezra Feilden, and Adi Oltean explain how they built a working prototype in just 15 months — and why big tech is racing to space for AI compute.

Inside The Startup Launching AI Into Space

Most founders think hiring is about interviewing. But it's actually about selling.For Startup School, Juicebox co-founder & CEO David Paffenholz joins YC's Harj Taggar to share how early-stage founders can find, pitch, and close top engineering and sales talent— from crafting better outreach to winning great hires from Big Tech— even when you're an unknown startup.

How To Recruit The Best Engineers And Sales Reps

Jake Heller is the co-founder & CEO of Casetext, the AI legal startup behind CoCounsel, which was acquired by Thomson Reuters for $650 million.In his talk at AI Startup School on June 17th, 2025, he shared how his team did it—from picking the right idea to building AI products that actually work—and how founders can turn a cool demo into a reliable tool used by real customers.

From Idea to $650M Exit: Lessons in Building AI Startups

Nearly every modern AI model, from ChatGPT and Claude to Gemini and Grok, is built on the same foundation: the Transformer.In this video, YC's Ankit Gupta traces how AI learned to understand language — from early RNNs and LSTMs to attention mechanisms and the breakthrough 2017 paper Attention Is All You Need — the discovery that unlocked the modern AI era.

Transformers: The Discovery That Sparked the AI Revolution

Every founder faces moments where they’re not sure what to do next — such as how to go to market with AI products, when to pivot, and who/when to hire.

In this episode of Office Hours, YC partners Pete Koomen, Brad Flora, Nicolas Dessaigne, and Gustaf Alströmer answer real questions from founders and share stories about how great teams build conviction, learn faster, and make better decisions as they grow.

YC Partners Answer Your Questions | Office Hours

For years, we've heard two major narratives about AI. One predicting the end of human work, the other dismissing it as hype. The truth is more nuanced, and more hopeful.From radiology to software engineering, the pattern repeats: as technology makes tasks cheaper and faster, demand for human creativity and judgment grows.YC's Garry Tan explores what history, economics, and real companies show us— that technology doesn't replace people, it redefines what we can do.

What Everyone Is Getting Wrong About AI And Jobs

John Jumper on June 16, 2025 at AI Startup School in San Francisco.

John Jumper is a physicist-turned-computational biologist who led DeepMind’s AlphaFold team—and earned the 2024 Nobel Prize in Chemistry for solving protein folding, a decades-old scientific challenge. 

In this talk, he shares how a deep learning breakthrough at CASP14 turned into AlphaFold 1 and then AlphaFold 2, delivering atomic accuracy predictions and revolutionizing biology. He explains the scientific puzzle behind protein folding, the key algorithmic breakthroughs, and the impact of making millions of protein structures accessible to researchers worldwide.

John Jumper: AlphaFold and the Future of Science

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