E34: “Angel” Podcast: George Zachary, General Partner at CRV shares insights on cancer scare shifting his focus to investing in health-tech, passing on Google at MDV, CRISPR & “designer babies”, coronavirus threat, origins of Sand Hill Road & more!

0:50 Jason intros CRV's George Zachary

2:20 Passing on Google at MDV and coming to peace with the anti-portfolio

5:51 Differences between leadership & management, where Steve Jobs, Larry & Sergey fell on that scale

10:27 Why 1990's VC was sales & marketing-driven instead of product-driven as it is now

12:52 What shifted the philosophy to product-driven businesses?

18:00 Meeting Elon Musk in the 1990's and backing Zip2

21:59 What were Seed investors like in the '90s? Origins of Sand Hill Road

25:48 Elon pitching Zip2 to a conglomerate of venture firms & selling Zip2 for cash

28:07 How VCs can be conceptually right and wrong in the outcome, how X.com merged with Confinity and became PayPal

33:27 Why is it harder to 3x the massive venture funds? How is age a limiting factor in VC?

40:28 "It doesn't make a difference what you pass on. It only takes 1 company to make your career." Positive & negative feedback cycles in VC.

42:54 Battling through multiple portfolio companies dying at once

44:15 What was George's biggest investment hit, both economically & personal fulfillment?

52:37 George describes his recent health scares and how they shifted his investment focus

1:04:06 Reasons the life-expectancy in the US has gone sideways in recent years

1:07:39 Potential health-tech advancements in the near future

1:21:58 Thoughts on CRISPR & "designer babies"

1:30:27 Cell-based fish & meat

1:37:32 Potential coronavirus repercussions - what's real and what's not?

1:55:13 Jason calls for eliminating handshakes