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Dr. Mark Hyman

Welcome to The Dr. Hyman Show, the groundbreaking podcast redefining health in America and empowering you to take ownership of your health. Hosted by Dr. Mark Hyman—this show tackles the most pressing issues of our time: chronic disease, mental health, food policy and controversy, prevention and recovery, and longevity. In an era where our food system fuels disease and outdated healthcare models fail to address root causes, Dr. Hyman delivers evidence-based insights and expert interviews to help you become the CEO of your own health—something your doctor isn’t doing.
The Dr. Hyman Show goes beyond the headlines to reimagine a food and healthcare system that protects health, unburdens our economy from the weight of chronic disease, supports the environment, and secures a vibrant future for all Americans. Whether you’re looking for cutting-edge protocols to transform your health, strategies to combat the chronic disease epidemic, or deep conversations about how wellness intersects with food, politics, and the environment, this podcast is your trusted guide. Rethink disease, claim your health, and join the movement for a healthier nation—tune into The Dr. Hyman Show today!

The Doctor's Farmacy with Mark Hyman, M.D.

Obesity is often seen as a matter of willpower, but science tells a different story. My guest today, Dr. David Kessler—former FDA commissioner, lawyer, physician, and the man who took on Big Tobacco—explains why biology, not blame, drives our struggles with weight.

On this episode of The Dr. Hyman Show, we talk about why weight struggles are so common today, what new drugs can and can’t do, and how his new FDA petition targets one of the biggest culprits: processed refined carbs. Catch the full conversation on YouTube, or listen wherever you get your podcasts.

[YOUTUBE THUMBNAIL]

You’ll learn:

• How food companies use ingredients like processed refined carbs to make products irresistible

• Why GLP-1 drugs help many lose weight—but can’t fix the food environment driving the crisis

• How belly fat fuels heart disease, diabetes, and cancer—and why ultraprocessed foods are a big part of the problem

• Simple ways to break free from foods engineered to make you overeat

• What Dr. Kessler’s FDA petition could mean for limiting processed carbs in our food supply and improving our collective health

Plus, here’s a bonus: We’ve adapted Dr. Kelsser’s petition into a free PDF guide—The Hard Truth About Processed Carbs—so you can see exactly how these ingredients affect your health…and why his FDA petition REALLY matters. 

Tune in, download the guide, and find out how you can be part of the solution.

View Show Notes From This Episode

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This episode is brought to you by Seed, Paleovalley, Function Health, Timeline and AirDoctor.

Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic.

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Obesity Isn’t Your Fault: Biology, Addiction & Solutions with Dr. David Kessler

Thyroid trouble often starts as a whisper—tiredness, stubborn weight, dry skin—until a closer look shows the tiny neck gland that sets the body’s “speed” is out of tune. Basic tests can miss the real issue, so checking active hormones and thyroid antibodies—and hunting for triggers like stress, gluten sensitivity, toxins, nutrient gaps, and gut imbalances—can reveal what’s really going on. When understood this way, thyroid health is no longer just about numbers on a lab report—it’s about restoring balance in the whole system. With the right testing, nutrition, and support, energy, mood, and metabolism can all return to their natural rhythm.

In this episode, I discuss, along with Dr. Elizabeth Boham and Dr. George Papanicolaou, thyroid conditions such as hypothyroidism, hyperthyroidism, thyroid autoimmunity and how Functional Medicine practitioners take a different approach to find the root cause of the imbalance.

Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women’s Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine.

Dr. George Papanicolaou is a graduate of the Philadelphia College of Osteopathic Medicine and is Board Certified in Family Medicine from Abington Memorial Hospital. Over time as the healthcare system made it harder for patients to receive personal care, Dr. Papanicolaou decided a change was needed. He began training in Functional Medicine through the Institute of Functional Medicine. In 2015, he established Cornerstone Personal Health—a practice dedicated entirely to Functional Medicine. In August 2017, I invited Dr. Papanicolaou to join The UltraWellness Center and we’ve been successfully helping people together ever since.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:How To Treat The Root Cause Of Thyroid Problems

Is An Underactive Thyroid To Blame For Your Mysterious Symptoms?

A Root Cause Approach to Hyperthyroidism and Graves’ Disease

From Fatigue to Freedom: Healing the Thyroid Beyond Lab Tests

For too long, psychiatry has treated mental illness as if it lives only in the brain. But what if the real story begins in the body? My guest today, Dr. Shebani Sethi, is a Clinical Associate Professor at Stanford and founding director of the Metabolic Psychiatry Program, the first clinic to unite psychiatry with nutrition and metabolism.

On this revealing episode of The Dr. Hyman Show, we explore how shifts in metabolism affect the brain and why this whole-body lens could transform how we prevent, understand, and treat mental health. Watch the full conversation on YouTube, or listen wherever you get your podcasts.

We discuss:

• How to recognize metabolic red flags behind mood and focus

• Tests you can ask for to uncover hidden drivers of mental health

• Everyday steps to restore brain energy and resilience

• Foods and nutrients that calm inflammation and support cognition

Dr. Shebani Sethi coined the term Metabolic Psychiatry, capturing what I’ve long believed and explored: that mental health begins in the body. Embracing this shift could reshape how we treat the mind and how we live each day.

View Show Notes From This Episode

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Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Big Bold Health, Sunlighten, Function Health, Paleovalley, Timeline and AirDoctor.

Get 30% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK30.

Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN.

Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership.

Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase.

Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today.

Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman.

Fix Your Brain by Fixing Your Body: Metabolic Psychiatry Explained by Dr. Shebani Sethi

Many people feel caught in worry, fear, and constant striving—chasing achievements yet never feeling truly fulfilled. The restless “monkey mind” jumps from one thing to the next, amplifying stress and turning setbacks into heavy burdens. It doesn’t have to be that way, though. You can move from mindless tasks to a mindful purpose. The shift begins by setting a clear, heartfelt intention rooted in something bigger. When the focus moves from self-gain to contribution, the right people, resources, and opportunities often begin to flow toward you. 

In this episode, Reverend Michael Beckwith, Lynne Twist, Jay Shetty, and I talk about how shifting from fear and self-focus to living with intention, surrender, daily spiritual practices, and a purpose larger than oneself can transform challenges into growth, bring deeper fulfillment, and open unexpected opportunities.

For over 30 years now, Reverend Michael Beckwith has embraced a practical approach to spirituality and has helped people see the benefits of meditation, affirmative prayer, and life visioning, a process he originated. He has spoken at the United Nations, hosted conferences featuring some of the top thinkers and leaders in a variety of industries, and he is also the founder of the Global Association for New Thought. He is a teacher, a speaker, and the author of several books. He has shared his insights on a number of well-known television programs, such as Oprah’s Super Soul Sunday, Dr. Oz, Larry King Live, CNN, Tavis Smiley, and others.

Lynne Twist has spent over 40 years working with more than 100,000 people in 50 countries in the realms of fundraising with integrity, conscious philanthropy, strategic visioning, and cultivating a healthy relationship with money. A renowned author and speaker, she has presented at the United Nations Beijing Women’s Conference, State of the World Forum, Synthesis Dialogues with Dalai Lama, and the Governor’s Conference on California Women. Recognized as a global visionary, Lynne has advised the Desmond Tutu Foundation and the Nobel Women’s Initiative. She co-founded the Pachamama Alliance, a nonprofit empowering Indigenous people of the Amazon rainforest to preserve their lands and culture. From serving with Mother Teresa in Calcutta to aiding refugee camps in Ethiopia and protecting the Amazon, her on-the-ground work has given her profound insight into the social fabric of the world and the defining challenges of our time.

Jay Shetty is a storyteller, podcaster, and former monk. Jay’s vision is to Make Wisdom Go Viral. He is on a mission to share the timeless wisdom of the world in an accessible, relevant, and practical way. Jay has created over 400 viral videos with over 7.5 billion views, and hosts the #1 Health and Wellness podcast in the world, On Purpose.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:

The Doctor's Farmacy: Episode 9 with Reverend Michael Beckwith

The Power Of Finding A Purpose Bigger Than Yourself

Finding Peace And Purpose By Thinking Like A Monk

How a Sense of Purpose Changes Your Brain, Body, and Future

Most women are told that midlife decline is inevitable—more aches, weaker bones, less strength. But is that really true?

On this episode of The Dr. Hyman Show, I sit down with Dr. Vonda Wright, a double-board certified orthopedic surgeon and leading voice in women’s longevity and performance. She shares how muscle functions as medicine, how hormones shape longevity, and why women’s midlife health deserves a whole new conversation. 

Join us for the full conversation on YouTube, or listen wherever you get your podcasts.

What you’ll discover:

• How to protect your strength, bones, and independence after 40

• Training shifts that build power, balance, and resilience you can feel every day

• Why hormone therapy may be safer and more effective than you’ve been told

• Nutrition habits that feed muscle, boost energy, and slow midlife decline

• The key tests that reveal your true healthspan—and how to act on them

Aging is universal, but frailty is not. With the right focus on strength, hormones, and lifestyle choices, women can move into midlife and beyond with vitality and independence.

View Show Notes From This Episode

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Join the 10-Day Detox to Reset Your Health

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Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Seed, Fatty 15, Function Health, Pique, PerfectAmino and BON CHARGE.

Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic.

Head to fatty15.com/hyman and use code HYMAN for 15% off your 90-day subscription Starter Kit.

Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership.

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Women 40+: Become Unbreakable (The Midlife Muscle Fix) w/ Dr. Vonda Wright

Many psychiatric labels—like bipolar disorder and schizophrenia—can obscure underlying biology, and symptom checklists often fail to explain or heal what’s really going on. Emerging evidence reframes mental illness as a problem of brain energy, mitochondria, and inflammation—shaped by insulin signaling, circadian rhythm disruption, the gut–brain axis, toxins, infections, and nutrient status. Metabolic interventions such as ketogenic nutrition, already established for epilepsy, show promise for rebalancing neurotransmitters, lowering neuroinflammation, and improving overall brain function. With depression now a leading cause of disability, shifting from “manage the symptoms” to “fix the biology” could dramatically improve outcomes where standard drugs fall short.

In this episode, Dr. Christopher Palmer, Dr. Todd LePine, Dr. Iain Campbell and I explore how rethinking mental illness as a metabolic and inflammatory disorder of the brain—rather than just a chemical imbalance—could transform the treatment and prevention of conditions like depression, bipolar disorder, and schizophrenia.

Dr. Chris Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health. He is the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School. For over 25 years, he has held leadership roles in psychiatric education, conducted research, and worked with people who have treatment-resistant mental illnesses. He has been pioneering the use of the medical ketogenic diet in the treatment of psychiatric disorders - conducting research in this area, treating patients, writing, and speaking around the world on this topic. More broadly, he is interested in the roles of metabolism and metabolic interventions on brain health.

Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders, and the neurobiology of mood and cognitive disorders. 

Dr. lain Campbell is the first academic research fellow to specialise in Metabolic Psychiatry as the Baszucki Research Fellow in Metabolic Psychiatry at the University of Edinburgh. He has a PhD in Global Health from the University of Edinburgh and is a principal investigator on a pilot trial of a ketogenic diet for bipolar disorder. He is a workstream lead and co-investigator on the first publicly funded research hub for Metabolic Psychiatry, the UKRI Medical Research Council Hub for Metabolic Psychiatry at the University of Edinburgh. His research in metabolic psychiatry has been published in Nature press journals Molecular Psychiatry and Translational Psychiatry and presented at Mayo Clinic Grand Rounds and The Royal College of Psychiatrists International Congress. 

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:A Harvard Psychiatrist Rethinks Mental Health As A Metabolic Disease

Is Brain Inflammation The Cause of Depression, Dementia, ADD, And Autism? A Functional Medicine Approach To Neuroinflammation

Is Bipolar Disorder Really a Diet Problem?

From Chemical Imbalance to Metabolic Breakthrough: A New Path for Mental Health

On this episode of The Dr. Hyman Show, I sit down with Nick Brewer, founder of Primal Moves—a method born from his own healing journey. Once a pro skier turned drug smuggler, he spent ten years in prison, including four in solitary, where he discovered the power of breath and movement to rebuild his body and mind.

I had the chance to try Nick’s class myself, and I was struck by how powerful such simple movements can be. I’m excited to share that experience with you. You can watch the full conversation on YouTube, or listen wherever you get your podcasts.

[YOUTUBE THUMBNAIL]

We discuss:

• How to spot when your nervous system is stuck—and steps to restore balance

• Why talk therapy alone can’t release trauma in the body

• How group movement triggers natural feel-good brain chemistry

• Why we feel cut off from our bodies and how to reconnect

Healing starts in the body. By working through stress and pain, we gain the strength and energy to show up fully in life. My hope is that this conversation encourages you to explore these practices and see what they unlock for you.

View Show Notes From This Episode

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https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive

This episode is brought to you by BON CHARGE, Timeline, Function Health, Big Bold Health, Paleovalley and LMNT.

Head to boncharge.com and use code DRMARK for 15% off your order.

Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today.

Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership.

Get 30% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK30.

Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase.

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From Drug Smuggler to Healer: How Nick Brewer Created Primal Moves

Inflammation is the body’s natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today’s most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging.

In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it’s important to be aware of systemic inflammation and how to address it.

Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications. 

Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others. 

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It?

The Silent Killer: Inflammation And Chronic Disease

How Silent Inflammation Accelerates Aging

The Silent Fire Behind Chronic Disease—and How to Put It Out

For decades, psychiatry has relied on treatments that are slow and often ineffective. But what if one intervention could reset the brain, break the grip of addiction, and open the door to an entirely new model of care? On this episode of The Dr. Hyman Show, I sit down with Dr. Nolan Williams, a Stanford neuropsychiatrist pioneering new therapies for substance use disorders, depression, PTSD, and traumatic brain injury.

We dive into these fascinating topics and more; watch the full conversation on YouTube or listen wherever you get your podcasts.

You’ll learn:

• Why ibogaine is unlike any other psychedelic—and how it could reset the brain

• Its promise for treating substance abuse disorders and breaking cycles of addiction

• The safety step that makes ibogaine treatment possible for real patients

• Why psychiatry is shifting from trial-and-error to targeted brain circuits

Talks like this remind me just how close we are to real breakthroughs in mental health. Dr. Williams calls it psychiatry 3.0. It’s a new era of treatments that actually heal the brain, and it gives me great hope for the future of medicine.

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

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Sign Up for Dr. Hyman’s Weekly Longevity Journal

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Join the 10-Day Detox to Reset Your Health

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Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Seed, Sunlighten, Function Health,Timeline, AirDoctor and Pique.

Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic.

Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN.

Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership.

Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today.

Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman.

Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.

One Dose That Heals Addiction, PTSD, and Brain Injury? Dr. Nolan Williams on The Science of Ibogaine

Nutrients are far more than supplements on a shelf—they are life-sustaining molecules that determine how well the body ages and resists disease. For years, their importance was overlooked because many studies were poorly designed, failing to consider existing nutrient levels or how vitamins and minerals work together. Strong evidence now shows multivitamins can slow brain aging, omega-3s can extend life expectancy, and shortages of vitamin D, magnesium, and B12 are widespread drivers of inflammation and chronic illness. Knowing and addressing individual deficiencies is critical, as these nutrients power billions of chemical reactions every second and are foundational to vitality and longevity.

In this episode, I discuss, along with Dr. Rhonda Patrick and Steve Martocci, why nutrients are essential for a healthy body and how to choose the highest quality supplements.

Dr. Rhonda Patrick is a scientist and health educator recognized for her leadership in aging and disease prevention. As the founder of FoundMyFitness, she provides evidence-based insights to a global audience through her website and podcast. On YouTube, she engages millions in in-depth discussions on evidence-based strategies for well-being. Dr. Patrick’s focus areas include genetic influences in dietary response, micronutrients, sleep, non-pharmacological approaches to mental well-being, and the surprising and paradoxical benefits of biological stressors such as exercise, heat, cold exposure, and plant phytochemicals. As an associate scientist and board member at the Fatty Acid Research Institute, she advances understanding of omega-3 fatty acids in aging and health. Her research has been published in high-impact journals like Nature Cell Biology, Experimental Gerontology, and FASEB.

Steve Martocci is the co-founder and CEO of Suppco, a smart supplement tracking platform helping people take the right supplements with confidence. After years of struggling with his health and hitting 300 pounds, Steve turned to functional medicine and supplements to reclaim his well-being. That personal transformation—and the confusion he faced along the way—inspired him to build Suppco. Suppco helps users track what they’re taking, avoid unnecessary or low-quality products, and personalize their supplement routine with tools like brand TrustScores, protocol guides, and stack analysis.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:

The Nutrient Gaps That Could Be Aging You Faster

My Favorite Supplements for Optimal Health & Longevity

How to Choose the Right Supplements (and Avoid the Wrong Ones)

The Nutrient Blueprint for a Longer, Healthier Life

Humans have coevolved with food and its medicinal actions on our bodies, meaning we have actual cell receptors for specific food-derived molecules. So why aren’t doctors trained in how to use food as medicine? We’re taught all about using pharmaceuticals to affect our biology, but the power of food is left high and dry. I think this is a foundational area of medical training we need to change. That’s why I’m so excited to talk to one of my favorite people and thinkers in the world of food and medicine on this episode of The Dr. Hyman Show, Dr. William Li. 
View Show Notes From This Episode
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Encore: How To Use Food As Medicine with Dr. William Li

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