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Reid Hoffman

What if, in the future, everything breaks humanity's way? Possible is an award-winning, weekly podcast that sketches out the brightest version of the future—and what it will take to get there. Hosts Reid Hoffman and Aria Finger explore what’s possible with forward-thinking leaders, deep thinkers, and ambitious builders across many fields, such as technology, art, education and healthcare. These conversations center on the ways technology—and, in particular, AI—is shaping the future. In episodes, AI tools such as OpenAI’s GPT-4 and Inflection’s Pi are at work, offering informational asides, prompting guests, or demoing what they can do. Lastly, between guest episodes, Aria interviews her co-host Reid on his latest takes on what’s possible if we use technology—and our collective effort—effectively.

Possible

This week Reid and Aria break down the global AI race from Nvidia’s $5 trillion valuation and the U.S.–China chip rivalry to what happens when AI starts reshaping industries like medicine. Reid explains why the future of innovation depends on how we deploy AI, not just how we build it, and why doctors, scientists, and creators will need to redefine their expertise in a world of intelligent tools. Later in the episode, Reid responds to new calls to “pause” AI development and shares why he believes safety and progress must advance together. The conversation ends with a look at the future of healthcare and why, in Reid’s view, AI won’t replace doctors, but doctors who use AI will replace those who don’t.

Reid riffs on NVIDIA's chips, China’s AI ambitions, and the push to pause AI

What does it take to turn tragedy into advocacy, and advocacy into lasting change? This week, Reid and Aria are talking to Warriors head coach Steve Kerr and Kris Brown, president of Brady, the nation’s oldest gun violence prevention organization. Together, they explore how sports, storytelling, and civic engagement can move the needle on one of America’s most polarizing issues: guns.

In the first part of this episode, Steve and Kris share the personal and political roots of their partnership. They also dive into the movement for safer gun storage, smart firearm technology, and the bipartisan momentum that’s possible when we lead with empathy over fear.

In the second part, the conversation turns to the future of basketball and leadership. Steve reflects on lessons from Phil Jackson and Gregg Popovich, the power of authenticity and collaboration, and how AI, analytics, and even robotics are reshaping the NBA. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

Topics:

01:14 - Hellos and intros

03:28 - Collaboration is the cornerstone of Steve’s leadership philosophy 

04:22 - Imposter syndrome, playing under Phil Jackson and Greg Popovich, and coaching Draymond Green 

06:02 - Steve’s personal experience with gun violence and using his platform to drive change

07:17 - Lessons Kris learned from working on the Brady Bill 

10:43 - Gemini explains the landmark Brady Bill and how it passed

11:48 - Origins of Steve and Brady’s partnership 

16:55 - Building bipartisan support for gun violence prevention, like the Bipartisan Safer Communities Act

21:21 - Smart gun technology, gun safes, and other technological solutions

25:27 - “Shut up and dribble” comment and the pushback athletes receive when they speak up

27:29 - Social media as a tool to create cultural change 

29:39 - Kris answers the last rapid-fire question and says her goodbyes

32:33 - Midroll

32:38 - Steve digs deeper into Phil Jackson and Greg Popovich’s coaching styles

34:40 - Inspiration v. comparison

35:22 - Hiring staff who bring specific strengths helps form a stronger team

36:21 - Endgame instincts as a coach

39:37 - Helping players navigate modern-age attention and public opinions on social media

42:01 - Internal leadership from players is crucial and Steph Curry as an example

44:33 - How NBA analytics have evolved

46:52 - The Warriors are planning to implement AI-powered robots into their training

47:56 - Players wear monitors that analyze their performance data

49:17 - Discoveries from players’ performance data 

50:46 - Analyzing game footage with AI, facial recognition technology, and learning that Steph Curry logs the most miles ran per game in the league

52:56 - Using game footage data to learn opponents’ patterns and build game plans

54:05 - Correlating physical condition and shot success percentage for each player

56:19 - Rapid-fire questions 

Select mentions: 

Phil Jackson

Greg Popovich

Brady Bill

Uvalde school shooting

Bipartisan Safer Communities Act

End Family Fire Campaign

Maxwell Frost

Matthew McConaughey

Dan Grunfeld

Lopez Twins

Maverick: More than a Game by Phil Jackson and Charley Rosen

Daryl Morey

A Gentleman in Moscow by Amor Towles

March for Our Lives

Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

Steve Kerr and Kris Brown on Leadership, Purpose, and Innovation in Sport and Society

Can AI help us better understand animals and, if it could, what might we discover? This week’s episode was recorded live at the 2025 Masters of Scale Summit where Reid and Aria sat down with Aza Raskin, co-founder and CEO of the Earth Species Project. Aza and his team are using AI to decode the languages and cultures of non-human species. From dolphins that invent new tricks together to crows that raise each other’s young in communal “villages,” Aza reveals the startling complexity of animal communication and what it teaches us about our own. During the course of their conversation, Reid, Aria and Aza explore why recognizing the intelligence of the animal kingdom might spark a new Copernican Revolution, one that changes not just science, but who we believe ourselves as a species to be. It’s a thought provoking journey through language, empathy, and the limits of human perspective that will make you listen to the natural world a little differently.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Topics:

00:00 – Live introduction from the Masters of Scale Summit

00:58 – Aza Raskin explains the Earth Species Project and its mission

03:03 – How AI can decode animal language and culture

05:18 – Crows, whales, and dolphins—evidence of communication and community

07:32 – What we’ve missed by only “hearing the shouts” of other species

08:30 – Dolphins learning to innovate together and what it reveals about intelligence

09:57 – Elephants’ overlapping calls and the idea of “communal grammar”

12:33 – From speaking to listening: the ethics of interspecies understanding

14:23 – Names, self-awareness, and identity across dolphins, elephants, and belugas

16:05 – Animal rituals, drum languages, and AI’s early attempts at conversation

18:10 – Animal Language Processing as science’s next frontier

20:38 – The moral shift: what animals teach us about empathy, AI, and responsibility

Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

Aza Raskin on interspecies communication, empathy, and AI’s next frontier

In this week's episode, Reid and Aria unpack why trust is a practical skill, not just a feeling. Reid riffs on the importance of hands-on investor-founder relationships, boardroom decisions that can make or break a company, and investor behaviors that build durable trust. They also discuss what product teams and policymakers must do to earn user confidence in an age of AI. Along the way, Reid shares personal anecdotes regarding his work with OpenAI, crisis leadership, and bridging Silicon Valley policy with the rest of the globe.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Reid riffs on fostering trust with founders, in boardrooms, and in AI

How can AI really help advance medicine? Should patients and care teams be seeking second opinions from LLMs? This week, Reid and Aria sit down with physician-scientist Dr. David Fajgenbaum, who repurposes existing drugs to save lives—including his own. David shares his journey from receiving last rites as a young medical student to co-founding Every Cure, a nonprofit using AI to come up with ways existing drugs can be repurposed to treat every disease and every patient possible. On this special episode, filmed live in New York City, David, Reid, and Aria explore the circuit of hope, action, and impact that drives medical discovery; the technical and ethical challenges around accelerating AI in healthcare; “agent optimization” as the new “search engine optimization;” and what a future of faster diagnoses and treatment could look like. The result is a conversation about resilience, innovation, and unlocking cures that are already within our reach.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

Topics:

3:00 - Hellos and intros

3:29 - A promise to his mother and the origin of AMF

6:23 - From grief support to medical school

9:18 - Near-death experiences and founding a research network

14:38 - What kept David going at death’s door

16:19 - Discovering a potential treatment and testing it on himself

19:42 - Why drug repurposing is a faster, cheaper complement to drug discovery

22:14 - Co-founding Every Cure and scaling discovery with AI

25:20 - Demo: Building MATRIX and how the algorithm makes predictions

28:41 - Breast cancer and Lidocaine as a case study

30:07 - Why human review is essential in AI for medicine

34:08 - Car exhaust fumes example and FDA pathways

37:31 - Reid’s surprise million-dollar donation for Every Cure compute

39:24 - What AI can unlock across healthcare

41:46 - Building an impact team to close the repurposing loop

47:32 - Improving systemic incentives for generics

54:58 - FDA approval pathways and label change challenges

57:21 - Three life-saving repurposing stories

1:02:20 - Rapid-fire questions

Select mentions: 

Hidden Potential by Adam Grant

Chasing My Cure by Dr. David Fajgenbaum

Every Cure 

David’s TED Talk: https://youtu.be/sb34MfJjurc?si=GcVleWHZuJ9MqLgS

Manas AI

Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

David Fajgenbaum on drug repurposing, AI, and saving his own life

This week, Reid and Aria dive into the debate over new $100,000 fees on H-1B visas, and discuss how immigration powers U.S. innovation and how to ensure startups aren’t shut out. They also cover developers’ mixed feelings about using AI in coding, the leap from 60% to 85% accuracy in medical AI predictions, and what it will take to bring regulators and clinicians on board. Plus, Reid shares why he’s skeptical of a three-day work week and reflects on the Trust in American Institutions Challenge, highlighting some inspiring finalists.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Reid riffs on Trump’s $100K visa fee, 3-day work weeks, and AI trust issues

What’s the role of semiconductors—and the companies that make them—in powering human progress? What does it look like to innovate thoughtfully in a landscape where the demand for power may be higher than the supply? With AI evolving faster and faster, how can we keep up? 

Advanced Micro Devices (AMD) CEO Lisa Su joins the show to talk about hardware, global manufacturing, and risk-taking. She shares what she has learned leading AMD from near-bankruptcy a decade ago to its current standing as one of the world’s leading chipmakers. Lisa also weighs in on geopolitics, the AI arms race, startups, what makes her want to hire someone, and AI’s enormous potential to advance healthcare for humankind. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

Topics:

2:46 - Hellos and intros

2:54 - The origins of Lisa's interest in hardware

4:19 - Deciding to bet on chips

6:06 - MIT and early engineering days

6:28 - Google Gemini defines "bunny suits"

8:25 - Differences between AMD and NVIDIA

10:25 - AI’s potential to improve healthcare

16:27 - Driving AMDs comeback

19:40 - Making patience and long-term vision a company-wide virtue

22:06 - Vision for the next 10 years

24:59 - Midroll

25:16 - The impact of geopolitics on AMD

28:38 - Environmental implications of chip production 

30:41 - Major hardware innovations in the start-up space

32:14 - AI driving coding acceleration

33:47 - How AMD encourages employees to leverage AI

35:22 - Identifying and empowering talent 

39:08 - Rapid-fire questions

Select mentions: 

Liquid.ai

The Worlds I See by Dr. Fei-Fei Li 

Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

Lisa Su on semiconductors, compute, and big bets

This week, Reid and Aria discuss Apple’s new AirPods Pro 3 and live translation capabilities, AI-generated movies (specifically Critterz from OpenAI), and what really could be lost — or gained — as AI technology becomes more widespread. Plus, Reid reflects on his speech at the Bologna Business School two years ago, and how far AI has come since then in amplifying creativity and humanity. 

Select mentions: 

Superagency

Bro-Botz (https://www.youtube.com/@Bro-BotzDTI) 

Reid’s Bologna Business School commencement speech 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Reid Riffs on AI translations, Apple Intelligence, and OpenAI’s Critterz

What could we gain—and what might we lose—when technology begins to approximate the contours of human connection and presence? In this episode, Reid and Aria chat with comedian, actor, and political commentator Stephen Colbert. Best known for hosting The Colbert Report and The Late Show, Stephen combines a razor sharp satire with a sincere curiosity about the world. Together, Reid, Aria, and Stephen discuss the art of live performance, the many lessons one can learn from J.R.R. Tolkien, and the nature of creativity, humor, and imagination in the age of AI. The result is a meditation on discovery, empathy, and the bonds that make connection more than performance — but a shared act of being human.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

Topics:

2:35 – Hellos and intros

2:53 – Stephen Riffs on humanity and Dungeons & Dragons 

6:08 – Tolkien characters and desert island companions

7:02 – Creativity, empathy, and imagination in comedy

11:37 – Performing for a live audience

13:02 – Comedy as a third space

16:22 – Early ideas about interactive technology and improvisation

19:14 – Can AI art escape the uncanny valley

22:27 – The human “micronutrients” that AI cannot replace

24:05 – Parasocial relationships and the future of entertainment

26:50:– Midroll

26:58 – Responsibility and fact-checking

29:56 – Personalization versus discovery in AI storytelling

33:47 – Lessons from Tolkien

41:22 – AI as part of human evolution

44:51 – How AI can already be employed in health fields

48:46 – AI in video games and creative amplification

49:58 – Balancing skepticism and excitement about AI

50:06 – Rapid-fire Questions

Select mentions: 

A Man Jumps Out of an Airplane by Barry Yourgrau

Exploring The Lord of the Rings with Dr. Corey Olsen

Letter 144 by J.R.R. Tolkien 

Robert Heinlein

Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

Stephen Colbert on connection, discovery and human nature

This week, Reid and Aria discuss the challenges around integrating AI into organizations and workspaces, China’s recent pivot away from NVIDIA, and OpenAI’s new $50 million NGO-focused fund. Reid also offers his take on a recent Stanford study that looks at entry-level jobs at risk of AI replacement. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Reid riffs on NVIDIA's chips, China’s AI ambitions, and the push to pause AI

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