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BBC Radio 4


Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future


The Life Scientific

"My ideas are often labelled as impossible, or useless, or both. Usually when people say that I'm on the right track."

George Church is a geneticist, molecular engineer, and one of the pioneers of modern genomics. He's also someone who makes a habit of finding solutions to the seemingly impossible.

Over the course of his career so far, George developed the first method for direct genomic sequencing, helped initiate the Human Genome Project, and founded the Personal Genome Project: making huge quantities of DNA data publicly available for research. Today, as a professor at Harvard Medical School and MIT, he’s working on some of the most headline-grabbing - and controversial - science on the planet: from the so-called "de-extinction" of woolly mammoths, to growing transplant-suitable organs in pigs, to virus-proofing humans.

When inspiration strikes, there seems to be little that will slow him down - even the fact that he has narcolepsy, the neurological disorder that causes sudden sleep attacks. In fact, as George tells Professor Jim Al-Khalili, some of his best ideas come in those moments between waking and sleep...

Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios

George Church on reimagining woolly mammoths and virus-proofing humans

Movies might have us believe that bomb disposal comes down to cutting the right wire. In fact, explosive devices are complex and varied - and learning how to dispose of them safely involves intense training, as well as the ability to stay calm under pressure. 

This was the world of Dr Gareth Collett, a retired British Army Brigadier General and engineer, specialising in bomb disposal; whose 32-year military career took him around the world, including heading up major ordnance clearance projects in Iraq and Afghanistan. After retiring from the army, Gareth became a university lecturer – but following his diagnosis with bladder cancer, started researching a possible link between bomb disposal veterans and higher rates of urological cancers.

In conversation with Professor Jim Al-Khalili, Gareth discusses this ongoing research, dealing with PTSD - and why he just can't watch Oscar-winning movie The Hurt Locker...

Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios

Gareth Collett on a career in bomb disposal

Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the fastest-growing neurological condition in the world. Today it affects around 11.8 million people and that’s forecast to double by 2030. 

Dr Sonia Gandhi is one of the scientists working to change that trend. As Professor of Neurology at University College London and Assistant Research Director at the Francis Crick Institute, her work involves using stem cells to build models of the human brain, helping to drive the development of drugs and other therapies for Parkinson’s patients.

Talking to Professor Jim Al-Khalili, Sonia explains why this destructive condition is on the rise - and the promising routes they're studying to find new ways to tackle it.

Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios

For details of organisations that offer advice and support to anyone affected by Parkinson's Disease, please go online to bbc.co.uk/actionline.

Sonia Gandhi on building model brains to tackle Parkinson’s disease

How do you feel about snakes? What about highly venomous ones?

For Mark O’Shea, close encounters with the world’s most rare and deadly snakes are not only his profession, but his passion. 
Mark is a Professor of Herpetology - the area of zoology focusing on reptiles and amphibians - at the University of Wolverhampton.

After dropping out of college in his teens, Mark's life could have taken a very different direction; but prompted by a fascination with reptiles that started with a childhood trip to the zoo, he's gone on to have a career spanning research, international expeditions and broadcasting. He's also worked with international medical teams, studying deadly species and helping to generate antidotes for some of the world’s deadliest venoms.

In conversation with Professor Jim Al-Khalili, Mark reveals the challenges around generating antivenom for countries that need it, the pros and cons of keeping snakes as pets, and what you need to know if you ever get bitten...

Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios

Mark O'Shea on close encounters with venomous snakes

There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysics and trauma medicine, to working with NASA, to becoming an Air Ambulance doctor.

Kevin is a consultant anaesthetist and professor of public engagement and innovation at University College London. He’s worked on the front line in hospitals, dealing with major incidents and helping shape policy; but he's also stayed true to his childhood passion for space, working on multiple projects with NASA and even going through the astronaut application process himself. As if that wasn’t enough, he’s also become a well-known figure in science broadcasting through his various radio and TV shows.

Speaking to Professor Jim Al-Khalili, Kevin admits it hasn't always been an easy path – but his passion for both space and medicine have got him through. And today, he's channelling his energies into ensuring we protect the NHS's most precious commodity: its staff.

Presented by Jim Al-Khalili
Produced by Lucy Taylor

This programme was a BBC Studios Audio prouction for Radio 4.

Kevin Fong on medical planning for Mars and Earth-based emergencies

Chemical reactions are the backbone of modern society: the energy we use, the medicines we take, our housing materials, even the foods we eat, are created by reacting different substances together. If we zoom in, it’s the atoms within these substances that rearrange themselves to give rise to new substances with the properties we need. 

However, chemical reactions are far from perfect. They're often inefficient and their waste products can be harmful to the environment. Getting to grips with what goes on at the scale of individual atoms has long been a sticking point.

Dame Pratibha Gai has spent much of her career pioneering novel microscopes to bring this seemingly inaccessible atomic world into sharp focus. Now Emeritus Professor of Chemistry at York University, her microscope, known as the environmental transmission electron microscope, is housed in labs around the world. It allows scientists, like herself, to observe chemical reactions in real-time, in exquisite atomic detail, and tinker with them to create products that are not only better for all of us, but also the environment.

Presented by Jim Al-Khalili
Produced by Beth Eastwood
A BBC Studios Audio production for Radio 4

Dame Pratibha Gai on training atoms to do what we want

Have you ever considered the lighter side of dark matter?
Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand. 

Astrophysicist Catherine Heymans is a Professor at the University of Edinburgh and the current Astronomer Royal for Scotland. She’s spent her career studying dark matter and dark energy: the mysterious ingredients that make up an estimated 95% of our cosmos, but which we still know surprisingly little about. Using increasingly powerful telescopes, both on earth and in space, Catherine has spent years building detailed maps of dark matter - even to the extent of capturing rare images of this mysterious cosmic component.

On top of her research achievements, she's committed to making science accessible to all; not least by taking an astronomy-themed comedy show to the Edinburgh Festival and beyond. 

In conversation with Professor Jim Al-Khalili, Catherine talks about her passion for sharing the joys of astrophysics - and reveals how health challenges over the last few years have forced her to readdress her career, her ambitions and even her sense of self... 

Presented by Jim Al-Khalili
Produced by Lucy Taylor

Catherine Heymans on the lighter side of the dark universe

As a young man, traveling in Africa, Tim Coulson - now Professor of Zoology at the University of Oxford - became seriously ill with malaria and was told a second bout would probably kill him. Aged only 20, this brush with his own mortality led him to promise himself he would write a complete guide to science: life, the universe and everything. His aim was to understand the existence of all living things - no mean feat!

Over the course of a colourful career, Tim's work has taken him all over the world: including researching wolves in Yellowstone National Park, little fish called guppies in the rivers of Trinidad and silvereye birds on Heron Island on the Great Barrier Reef. Using complicated mathematical models he builds up a picture of ecosystems seeking to explain how predators impact both evolution and ecosystems. And finally, more than thirty years after he vowed to write the book that would explain everything we know about science, he's done just that.

In conversation with Professor Jim Al-Khalili, Tim talks about his journey from youthful ambition to science demystifier.

Presented by Jim Al-Khalili
Produced by Geraldine Fitzgerald

Tim Coulson on how predators shape ecosystems and evolution

Claudia de Rham has rather an unusual relationship with gravity. 

While she has spent her career exploring its fundamental nature, much of her free time has involved trying to defy it - from scuba diving in the Indian Ocean to piloting small aircraft over the Canadian waterfalls. Her ultimate ambition was to escape gravity’s clutches altogether and become an astronaut, a dream that was snatched away by an unlikely twist of fate. 

However, Claudia has no regrets - and says defying gravity for much of her life has helped her to truly understand it. 

As Professor of theoretical physics at Imperial College London, she now grapples with deep mathematics, where the fields of particle physics, gravity and cosmology intersect, on a quest to understand how the universe really works. She is a pioneer of the theory of massive gravity, a theory which could take us beyond even Einstein’s theory of relativity and shed light on why the universe is expanding at an ever-increasing rate.

Presented by Jim Al-Khalili
Produced by Beth Eastwood

Claudia de Rham on playing with gravity

When you think of Artificial Intelligence, does it inspire confidence, or concern?

Although it's now generally accepted that this technology will play a major role in our future, a lot of conversations around AI and machine learning come back to the argument over us losing control and robots taking over. 

Happily, Neil Lawrence has a more optimistic view of the power of AI, and how we might navigate the potential pitfalls. Neil is the DeepMind Professor of Machine Learning at the University of Cambridge, and over the course of his career has been involved in deploying AI and machine learning in both academic and commercial scenarios, with a stint at Amazon as well as working across fields as varied as movie animation, Formula 1 strategy, and medical research.

Speaking with Professor Jim Al-Khalili, Neil says ultimately his efforts are all about making a difference to our everyday lives - and that we need to learn how to embrace AI, albeit with a healthy dollop of scepticism; not least when it comes to how our data is used, and the power of 'the digital oligarchy'...

Presented by JIm Al-Khalili
Produced for BBC Studios by Lucy Taylor

Neil Lawrence on taking down the 'digital oligarchy' and why we shouldn't fear AI

Sir Shankar Balasubramanian is responsible for a revolution in medicine. The method he invented for reading, at speed, the unique genetic code that makes each one of us who we are, is ten million times faster than the technology that was used in the human genome project at the turn of the century. What’s more, it can be done much more cheaply than before and on a desktop machine. And it’s transforming healthcare, by helping us to understand the genetic basis of many diseases (particularly cancers) and to develop new diagnostic tests, medicines and personalised treatments. 
‘DNA has never failed to keep me excited and curious’ says Shankar, winner of the highly prestigious 2022 Breakthrough Prize in Life Sciences. He didn’t set out to create a game-changing technology or to make a lot of money. He just wanted to understand the DNA double helix in the greatest possible detail; to reveal how it worked, molecule by molecule. And he still rides a rickety old bicycle to work in Cambridge. 
Producer: Anna Buckley

Image ©University of Cambridge

Shankar Balasubramanian on decoding DNA

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