Picking up exactly where Playing Gods 1: Isolation left off, Playing Gods 2: Adaptation brings the zehuderan warriors Xriah and Vylis to the world of Gravios. A far cry from the last plane where the two battled, Gravios is an ocean world of cybernetically augmented humans and post-apocalyptic sea vessels. All land on Gravios has been completely submerged into the depths, the sea level elevated by the planet-swallowing marine creature known as the Grava. In this arena of hostile waters and cyborg warriors, this plane's denizens may prove a more formidable factor than others have been in this endless two-man war. It should be an easy victory for Vylis, though. After pushing his foe past the breaking point, Vylis should be able to capitalize on one of Xriah's trademark mistake-filled rages. This time, however, things are different. Xriah is different, and this new Xriah might just be a little more calculating than Vylis bargained for.

Meanwhile, the goddess Synandri's right hand man Xzarius is rewarded for his heroic efforts on the last plane with a new task: assisting another zehuderan named Vellady in her ascension to the Nexusplane. The eventual fate of all successful zehuderan, ascension is the ultimate trial, presenting challenges few zehuderan are equipped to handle. Even with the help of Xzarius, these new obstacles may prove too unfathomable for Vellady to overcome.

With lives so long, the routines so ingrained, change is difficult. Our coping strategies for new challenges are themselves challenged, and survival itself is often at stake. The only way to overcome change is to embrace it. The only way to survive is to Adapt ...