The story follows Walter Gilman, who takes a room in the Witch House, an accursed house in Akham, Lovecraft's fictional New England town. The house once harbored Keziah Mason, a witch who disappeared mysteriously from a Salem jail in 1692. Gilman discovers that over the centuries most of its occupants have died prematurely. In his dreams while at the house, Gilman travels to the city of Elder Things and communes with the evil witch and her henchmen.