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Michael Kennedy

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive
 deep into the popular packages and software developers, data scientists, and incredible hobbyists doing
 amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community
 by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite
 packages and the hot new ones coming out of open source.

Talk Python To Me

In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three cities and a dozen hospitals. He asked around about how researchers keep track of that. The answer was Microsoft Excel. Shaun Chuah had written some HTML by hand in Notepad back in high school and that was about the whole of his programming experience, so he opened the Django tutorial and started reading. Six years later that app is Foundry120, holding 10 terabytes of clinical and genomics data with an agentic AI running on top of it.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Talk Python Courses

Links from the show
Guest

Shaun Chuah: github.com

Up and Running with Rust Course: talkpython.fm

Foundry120: www.foundry120.com

Designing Data Intensive Applications: www.oreilly.com

Microsoft Foundry: ai.azure.com

ChatIBD: www.chatibd.com

Blog: shaunchuah.github.io

@drshaunchuah: x.com

github.com/shaunchuah: github.com

Watch this episode on YouTube: youtube.com

Episode #560 deep-dive: talkpython.fm/560

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#560: Building a Research OS: From Django to 30,000 Samples

Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent fifteen years being the person companies call when an outage is costing them real money per hour, and his whole argument is that everything you'd want in that moment gets decided months earlier, on ordinary afternoons, when someone chose the convenient thing. We walk his top twelve dos and don'ts in AWS - infrastructure as code, IAM roles instead of access keys, private subnets, no wildcards, no public buckets - and I push on which of them actually matter if you're one person on a small VPS. Then we get to Cloud War Games, where Matt breaks things on purpose so your team's first real incident isn't their first incident. Let's get into it.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Talk Python Courses

Links from the show
Guest

Matt Lea: linkedin.com

Talk Python Certificates: training.talkpython.fm/certificates

Schematical: schematical.com

CloudWarGames.com: cloudwargames.com

Zero to Hero on AWS Security: www.oreilly.com

Repo: github.com

Custom Wheel Offset: customwheeloffset.com

2012 TechCrunch Disrupt Hackathon: techcrunch.com

tech comics: schematical.com

shhgit: github.com

Zero Trust in 200ms: Implementing Identity-Per-Transaction: us.pycon.org

Coolify: coolify.io

returned to full GA Nov 2025: aws.amazon.com

Signed URLs/cookies: docs.aws.amazon.com

Cloudflare: www.cloudflare.com

Bunny Shield: bunny.net

Cloud War Games One: www.youtube.com

Cloud War Games Two: www.youtube.com

LinkedIn: linkedin.com

YouTube: youtube.com

KnocKnoc: knocknoc.io

Watch this episode on YouTube: youtube.com

Episode #559 deep-dive: talkpython.fm/559

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#559: 12 Things You Should (and Shouldn't) Do in AWS

Every company has one. The little internal tool that Jane built back in 2021, and then Jane left. Nobody understands it, nobody will touch it. There are two unwritten rules around it: don't change it, it's working. And if you break it, you bought it. That's dark-matter enterprise software.

For every app you can actually see, there are ten of these sitting in the shadows, frozen. Michael Booth thinks that just changed. He read my article on hyper-personal software and ran with it, writing about hyper-team software: small teams inside big companies finally building the tools that were never going to get built.

We cover where this works, where it quietly goes wrong, and the guardrails that keep it from turning into a mess. Let's get into it.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Python in Production

Talk Python Courses

Links from the show
Guest

Michael Booth: github.com

Talk Python AI Integrations: talkpython.fm/blog

From Hyper-Personal to Hyper-Team Software: Small Team-Built, AI-Assisted Tools Inside the Enterprise: www.databooth.com.au

What hyper-personal software looks like (MK's article): mkennedy.codes

Databooth Site: www.databooth.com.au

Wall Street just lost $285 billion because of 13 markdown files: martinalderson.com

SaaSpocalypse is real but everyone is panicking about the wrong thing: www.reddit.com

Warp Terminal: www.warp.dev

Watch this episode on YouTube: youtube.com

Episode #558 deep-dive: talkpython.fm/558

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#558: Hyper-Personal Software with Python

Security has always been the vegetables of software. Everyone agrees it matters, and somehow it never quite makes it onto the plate. At PyCon US this year, that changed. For the first time ever, security got its own dedicated, day-long track, one of just two at the whole conference, sitting right next to AI. And the room was packed to the back wall.

On this episode, I'm joined by the three people at the center of it. Seth Larson, Security Developer in Residence at the Python Software Foundation and, very recently, a CPython core developer. Juanita Gomez, a PhD researcher at UC Santa Cruz in open source security, who co-chaired the track. And Mike Fiedler, PyPI's Safety and Security Engineer, one of the very few people paid full-time to keep the packages you install safe.

We use the arc of the track's talks to take the temperature of Python security right now: supply chain attacks, dependency cooldowns, zero trust, SBOMs, and the push to bring Rust into CPython. And why not one of us thinks security is anywhere close to solved. Turns out that's the good news. It's why the room was full.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show
Guests

Juanita Gomez: linkedin.com

Mike Fiedler: miketheman.dev

Seth Michael Larson: sethmlarson.dev

Trailblazing Python Security: us.pycon.org

Everything Security at PyCon US 2026 (PSF blog): pyfound.blogspot.com

Dependency Cooldowns: cooldowns.dev

Anatomy of a Phishing Campaign (Mike Fiedler) Recording: www.youtube.com

FedRAMP: www.gsa.gov

Zero Trust in 200ms: Implementing Identity-Per-Transaction with Python & Serverless-Tristan McKinnon: www.youtube.com

Rust for CPython project: blog.python.org

pre-PEP: discuss.python.org

Rust for CPython: Making Python Safer and More Robust for Everyone - Emma Smith: www.youtube.com

SBOMit: github.com

Asleep at the Wheel: Getting your SBOMs to pay attention... - Sanchit Sahay, Abhishek Reddypalle: www.youtube.com

Volatility: volatilityfoundation.org

Post Incident Runtime SBOM Generation from Python Memory - Hala Ali: www.youtube.com

zizmor: docs.zizmor.sh

GitHub Actions security in Python packages (Andrew Nesbitt write-up): nesbitt.io

andrew/pycon: data & analysis for the GitHub Actions security talk: github.com

GitHub Actions Security in Python Packages - Andrew Nesbitt: www.youtube.com

gh-profiler: examine a GitHub user's profile to gauge their contributions: github.com

PyCon US YouTube channel: www.youtube.com

SBOMit: adding verification to SBOMs (OpenSSF): openssf.org

Ecosystems: ecosyste.ms

Watch this episode on YouTube: youtube.com

Episode #557 deep-dive: talkpython.fm/557

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#557: Security of everything at PyCon 2026

For years, "Django and async" came with an asterisk. The docs themselves warned you off it. Scary performance notes, a story that felt half-finished. Well, that story just got rewritten, literally, and the person who rewrote it is here to tell you why the old framing was wrong.

Carlton Gibson is a former Django Fellow, sat on the security team for eight years, and he's on the steering council. On this episode we get into the async topic doc rewrite, what actually remains versus what was just fear, the new Tasks framework in 6.0, DB-level cascades and fetch modes landing in 6.1, and why free-threading is the bet that's about to pay off big for Django. If you've been told Django's async story isn't ready, this is the episode that puts that myth to bed.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Python in Production

Talk Python Courses

Links from the show
DjangoCon Europe: djangocon.eu

PyCon Italia: pycon.it

Django on the Med: djangomed.eu

Django Mantle: noumenal.es

PyPI: pypi.org

release notes: docs.djangoproject.com

on_delete: docs.djangoproject.com

Fetch modes: docs.djangoproject.com

HttpRequest.multipart_parser_class: docs.djangoproject.com

async topic doc: docs.djangoproject.com

docs: docs.djangoproject.com

DEP 14: github.com

django-tasks: github.com

django-tasks-local: github.com

Celery: docs.celeryq.dev

PEP 703: peps.python.org

free-threading HOWTO: docs.python.org

PEP 779: peps.python.org

ASGI: docs.djangoproject.com

PGBouncer: www.pgbouncer.org

Channels: channels.readthedocs.io

sync_to_async / async_to_sync: docs.djangoproject.com

noumenal.es: noumenal.es

Django Chat: djangochat.com

@carlton@fosstodon.org: fosstodon.org

Article: Cutting Python Web App Memory Over 31%: mkennedy.codes

Watch this episode on YouTube: youtube.com

Episode #556 deep-dive: talkpython.fm/556

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#556: Updates on Django's Async Story

Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state.

This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show
marimo pair: marimo.io/pair

Course transcripts announcement: talkpython.fm/blog

anywidget: Jupyter Widgets made easy: talkpython.fm

marimo: marimo.io

blog: marimo.io

GitHub: github.com

given this: martinalderson.com

llms.txt: talkpython.fm

mcp: talkpython.fm

cli: talkpython.fm

open issues: github.com

Discord: marimo.io

Marimo Pair: marimo.io

OpenCode: opencode.ai

AI Tooling for Software Engineers in 2026: newsletter.pragmaticengineer.com

Watch this episode on YouTube: youtube.com

Episode #555 deep-dive: talkpython.fm/555

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#555: Marimo Pair - A Canvas for Agent + Developers Collaboration

You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it.

Episode sponsors

Six Feet Up

Talk Python Courses

Links from the show
Guest

Sumit Gundawar: linkedin.com

Course transcripts announcement: talkpython.fm/blog

Sumit Gundawar - JAX London Speaker: jaxlondon.com

Anthropic: anthropic.com

OpenAI Platform: platform.openai.com

Anthropic: anthropic.com

LangChain: langchain.com

OWASP: owasp.org

Pydantic: pydantic.dev

EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu

HIPAA - HHS: www.hhs.gov

NHS: www.nhs.uk

Llama: llama.com

Qwen - QwenLM on GitHub: github.com

OpenAI Platform: platform.openai.com

Hugging Face: huggingface.co

Llama: llama.com

Granola: www.granola.ai

HIPAA - HHS: www.hhs.gov

CodeRabbit: www.coderabbit.ai

Cursor Origin: cursor.com

GitHub Status: www.githubstatus.com

Midjourney Medical: www.midjourney.com

Neko Health: www.nekohealth.com

CERN: home.cern

ATLAS Experiment: atlas.cern

Watch this episode on YouTube: youtube.com

Episode #554 deep-dive: talkpython.fm/554

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#554: Trustworthy AI in Healthcare and Longevity

This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Python in Production

Talk Python Courses

Links from the show
@calvinhp@sixfeetup.social: sixfeetup.social

@calvinhp.com: bsky.app

calvinhp.com: calvinhp.com

Original airing on Python Bytes: pythonbytes.fm

pi: pi.dev

superpowers: github.com

Warp.dev: Warp.dev

OhMyZSH: ohmyz.sh

Commandbookapp.com: Commandbookapp.com

Blink: blink.sh

kitty: sw.kovidgoyal.net

mosh: mosh.org

tmux: github.com

Claude code: www.anthropic.com

Claude.md: Claude.md

MacWhisper: goodsnooze.gumroad.com

Handy: handy.computer

Tailscale: tailscale.com

Talk Python episode with Alex: talkpython.fm

Telescopo: www.telescopo.app

Typora markdown: typora.io

formal documentation for many of my open source packages: mkennedy.codes

Great Docs: posit-dev.github.io

Statement on the US government directive to suspend access to Fable 5 and Mythos 5: www.anthropic.com

No second date: x.com

Watch this episode on YouTube: youtube.com

Episode #553 deep-dive: talkpython.fm/553

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#553: All of our tools

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show
Guest

Charlie Marsh: github.com

The announcement: astral.sh

OpenAI: openai.com

uv: github.com

ty: github.com

Ruff: github.com

pyx: astral.sh

Codex team: openai.com

Anthropic did something similar by acquiring Bun: www.anthropic.com

Daily Stars Explorer: emanuelef.github.io

Agentic AI Programming for Python: training.talkpython.fm

Python Web Security: OWASP Top 10 with Agentic AI: training.talkpython.fm

Episode #552 deep-dive: talkpython.fm/552

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#552: Astral joins OpenAI

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

Episode sponsors

AgentField AI

Talk Python Courses

Links from the show
Guests

Naunidh Bhalla: linkedin.com

Grant Gittes: linkedin.com

Marcel Kornacker: linkedin.com

Beon de Nood: linkedin.com

Chinmaya Joshi: linkedin.com

David Mytton: linkedin.com

Shea Tate-Di Donna: linkedin.com

Jason Rowley: linkedin.com

Azul Garza: github.com

Renée Rosillo: linkedin.com

Tetrix: tetrix.co

Tetrix Jobs: tetrix.co

Arcjet: arcjet.com

Pixeltable: pixeltable.com

Phemeral.dev: phemeral.dev

CapiscIO: capisc.io

Episode #551 deep-dive: talkpython.fm/551

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#551: Stroll Down Startup Lane - 2026

See the full show notes for this episode on the website at talkpython.fm/537

#537: Datastar: Modern web dev, simplified

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