Early one morning in New York City, Will Heller, a sixteen-year-old paranoid schizophrenic, gets on a New York City uptown B train on a fantastic and terrifying quest to save the world. Violet Heller, his frantic mother, is joined by Ali Lateef, a missing persons specialist, in a desperate attempt to locate her son before psychosis claims him completely. As the stakes grow higher, Lateef gradually comes to realize that this is more than a case of a runaway teen: Will Heller has a chilling case history, and Violet, beautiful and enigmatic, harbors a secret that Lateef will discover at his own peril.

Suspenseful and comic, devastating and hopeful by turns, Lowboy is a fearless exploration of youth, sex and violence in contemporary America, seen through one boy's haunting and extraordinary vision.