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Michael Kennedy

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive
 deep into the popular packages and software developers, data scientists, and incredible hobbyists doing
 amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community
 by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite
 packages and the hot new ones coming out of open source.

Talk Python To Me

You love building web apps with Python, and HTMX got you excited about the hypermedia approach -- let the server drive the HTML, skip the JavaScript build step, keep things simple. But then you hit that last 10%: You need Alpine.js for interactivity, your state gets out of sync, and suddenly you're juggling two unrelated libraries that weren't designed to work together. 

What if there was a single 11-kilobyte framework that gave you everything HTMX and Alpine do, and more, with real-time updates, multiplayer collaboration out of the box, and performance so fast you're actually bottlenecked by the monitor's refresh rate? That's Datastar. 

On this episode, I sit down with its creator Delaney Gillilan, core maintainer Ben Croker, and Datastar convert Chris May to explore how this backend-driven, server-sent-events-first framework is changing the way full-stack developers think about the modern web.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Command Book

Talk Python Courses

Links from the show
Guests

Delaney Gillilan: linkedin.com

Ben Croker: x.com

Chris May: everydaysuperpowers.dev

Datastar: data-star.dev

HTMX: htmx.org

AlpineJS: alpinejs.dev

Core Attribute Tour: data-star.dev

data-star.dev/examples: data-star.dev

github.com/starfederation/datastar-python: github.com

VSCode: marketplace.visualstudio.com

OpenVSX: open-vsx.org

PyCharm/Intellij plugin: plugins.jetbrains.com

data-star.dev/datastar_pro: data-star.dev

gg: discord.gg

HTML-ivating your Django web app's experience with HTMX, AlpineJS, and streaming HTML - Chris May: www.youtube.com

Senior Engineer tries Vibe Coding: www.youtube.com

1 Billion Checkboxes: checkboxes.andersmurphy.com

Game of life example: example.andersmurphy.com

Watch this episode on YouTube: youtube.com

Episode #537 deep-dive: talkpython.fm/537

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#537: Datastar: Modern web dev, simplified

You've built your FastAPI app, it's running great locally, and now you want to share it with the world. But then reality hits -- containers, load balancers, HTTPS certificates, cloud consoles with 200 options. What if deploying was just one command? That's exactly what Sebastian Ramirez and the FastAPI Cloud team are building. On this episode, I sit down with Sebastian, Patrick Arminio, Savannah Ostrowski, and Jonathan Ehwald to go inside FastAPI Cloud, explore what it means to build a "Pythonic" cloud, and dig into how this commercial venture is actually making FastAPI the open-source project stronger than ever.

Episode sponsors

Command Book

Python in Production

Talk Python Courses

Links from the show
Guests

Sebastián Ramírez: github.com

Savannah Ostrowski: github.com

Patrick Arminio: github.com

Jonathan Ehwald: github.com

FastAPI labs: fastapilabs.com

quickstart: fastapicloud.com

an episode on diskcache: talkpython.fm

Fastar: github.com

FastAPI: The Documentary: www.youtube.com

Tailwind CSS Situation: adams-morning-walk.transistor.fm

FastAPI Job Meme: fastapi.meme

Migrate an Existing Project: fastapicloud.com

Join the waitlist: fastapicloud.com

Talk Python CLI

Talk Python CLI Announcement: talkpython.fm

Talk Python CLI GitHub: github.com

Command Book

Download Command Book: commandbookapp.com

Announcement post: mkennedy.codes

Watch this episode on YouTube: youtube.com

Episode #536 deep-dive: talkpython.fm/536

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#536: Fly inside FastAPI Cloud

Building on the web is like working with the perfect clay. It’s malleable and can become almost anything. But too often, frameworks try to hide the web’s best parts away from us. Today, we’re looking at PyView, a project that brings the real-time power of Phoenix LiveView directly into the Python world. I'm joined by Larry Ogrodnek to dive into PyView.

Episode sponsors

Talk Python Courses

Python in Production

Links from the show
Guest

Larry Ogrodnek: hachyderm.io

pyview.rocks: pyview.rocks

Phoenix LiveView: github.com

this section: pyview.rocks

Core Concepts: pyview.rocks

Socket and Context: pyview.rocks

Event Handling: pyview.rocks

LiveComponents: pyview.rocks

Routing: pyview.rocks

Templating: pyview.rocks

HTML Templates: pyview.rocks

T-String Templates: pyview.rocks

File Uploads: pyview.rocks

Streams: pyview.rocks

Sessions & Authentication: pyview.rocks

Single-File Apps: pyview.rocks

starlette: starlette.dev

wsproto: github.com

apscheduler: github.com

t-dom project: github.com

Watch this episode on YouTube: youtube.com

Episode #535 deep-dive: talkpython.fm/535

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#535: PyView: Real-time Python Web Apps

Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on SQLite that can speed things up without spinning up Redis or extra services. Once you start to see what it can do, a universe of possibilities opens up. We're joined by Vincent Warmerdam to dive into DiskCache.

Episode sponsors

Talk Python Courses

Python in Production

Links from the show
diskcache docs: grantjenks.com

LLM Building Blocks for Python course: training.talkpython.fm

JSONDisk: grantjenks.com

Git Code Archaeology Charts: koaning.github.io

Talk Python Cache Admin UI: blobs.talkpython.fm

Litestream SQLite streaming: litestream.io

Plash hosting: pla.sh

Watch this episode on YouTube: youtube.com

Episode #534 deep-dive: talkpython.fm/534

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#534: diskcache: Your secret Python perf weapon

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in production. Deployment patterns, async gotchas, servers, scaling, and the stuff you only learn at 2 a.m. when the pager goes off. For Django, we have Carlton Gibson and Jeff Triplet. For Flask, we have David Lord and Phil Jones, and on team Litestar we have Janek Nouvertné and Cody Fincher, and finally Sebastián Ramírez from FastAPI is here. Let’s jump in.

Episode sponsors

Talk Python Courses

Python in Production

Links from the show
Guests

David Lord

Janek Nouvertné

Cody Fincher

Philip Jones

Jeff Triplett

Carlton Gibson

Carlton Gibson - Django: github.com

Sebastian Ramirez - FastAPI: github.com

David Lord - Flask: davidism.com

Phil Jones - Flask and Quartz(async): pgjones.dev

Yanik Nouvertne - LiteStar: github.com

Cody Fincher - LiteStar: github.com

Jeff Triplett - Django: jefftriplett.com

Django: www.djangoproject.com

Flask: flask.palletsprojects.com

Quart: quart.palletsprojects.com

Litestar: litestar.dev

FastAPI: fastapi.tiangolo.com

Coolify: coolify.io

ASGI: asgi.readthedocs.io

WSGI (PEP 3333): peps.python.org

Granian: github.com

Hypercorn: github.com

uvicorn: uvicorn.dev

Gunicorn: gunicorn.org

Hypercorn: hypercorn.readthedocs.io

Daphne: github.com

Nginx: nginx.org

Docker: www.docker.com

Kubernetes: kubernetes.io

PostgreSQL: www.postgresql.org

SQLite: www.sqlite.org

Celery: docs.celeryq.dev

SQLAlchemy: www.sqlalchemy.org

Django REST framework: www.django-rest-framework.org

Jinja: jinja.palletsprojects.com

Click: click.palletsprojects.com

HTMX: htmx.org

Server-Sent Events (SSE): developer.mozilla.org

WebSockets (RFC 6455): www.rfc-editor.org

HTTP/2 (RFC 9113): www.rfc-editor.org

HTTP/3 (RFC 9114): www.rfc-editor.org

uv: docs.astral.sh

Amazon Web Services (AWS): aws.amazon.com

Microsoft Azure: azure.microsoft.com

Google Cloud Run: cloud.google.com

Amazon ECS: aws.amazon.com

AlloyDB for PostgreSQL: cloud.google.com

Fly.io: fly.io

Render: render.com

Cloudflare: www.cloudflare.com

Fastly: www.fastly.com

Watch this episode on YouTube: youtube.com

Episode #533 deep-dive: talkpython.fm/533

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#533: Web Frameworks in Prod by Their Creators

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multiplying like gremlins snacking after midnight. On this episode, we have an amazing panel to give us a range of perspectives on what matter in 2025 in Python. We have Barry Warsaw, Brett Cannon, Gregory Kapfhammer, Jodie Burchell, Reuven Lerner, and Thomas Wouters on to give us their thoughts.

Episode sponsors

Seer: AI Debugging, Code talkpython26

Talk Python Courses

Links from the show
Python Software Foundation (PSF): www.python.org

PEP 810: Explicit lazy imports: peps.python.org

PEP 779: Free-threaded Python is officially supported: peps.python.org

PEP 723: Inline script metadata: peps.python.org

PyCharm: www.jetbrains.com

JetBrains: www.jetbrains.com

Visual Studio Code: code.visualstudio.com

pandas: pandas.pydata.org

PydanticAI: ai.pydantic.dev

OpenAI API docs: platform.openai.com

uv: docs.astral.sh

Hatch: github.com

PDM: pdm-project.org

Poetry: python-poetry.org

Project Jupyter: jupyter.org

JupyterLite: jupyterlite.readthedocs.io

PEP 690: Lazy Imports: peps.python.org

PyTorch: pytorch.org

Python concurrent.futures: docs.python.org

Python Package Index (PyPI): pypi.org

EuroPython: tickets.europython.eu

TensorFlow: www.tensorflow.org

Keras: keras.io

PyCon US: us.pycon.org

NumFOCUS: numfocus.org

Python discussion forum (discuss.python.org): discuss.python.org

Language Server Protocol: microsoft.github.io

mypy: mypy-lang.org

Pyright: github.com

Pylance: marketplace.visualstudio.com

Pyrefly: github.com

ty: github.com

Zuban: docs.zubanls.com

Jedi: jedi.readthedocs.io

GitHub: github.com

PyOhio: www.pyohio.org

Watch this episode on YouTube: youtube.com

Episode #532 deep-dive: talkpython.fm/532

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#532: 2025 Python Year in Review

Have you ever thought about getting your small product into production, but are worried about the cost of the big cloud providers? Or maybe you think your current cloud service is over-architected and costing you too much? Well, in this episode, we interview Michael Kennedy, author of "Talk Python in Production," a new book that guides you through deploying web apps at scale with right-sized engineering.

Episode sponsors

Seer: AI Debugging, Code talkpython26

Agntcy

Talk Python Courses

Links from the show
Christopher Trudeau - guest host: www.linkedin.com

Michael's personal site: mkennedy.codes

Talk Python in Production Book: talkpython.fm

glances: github.com

btop: github.com

Uptimekuma: uptimekuma.org

Coolify: coolify.io

Talk Python Blog: talkpython.fm

Hetzner (€20 credit with link): hetzner.cloud

OpalStack: www.opalstack.com

Bunny.net CDN: bunny.net

Galleries from the book: github.com

Pandoc: pandoc.org

Docker: www.docker.com

Watch this episode on YouTube: youtube.com

Episode #531 deep-dive: talkpython.fm/531

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#531: Talk Python in Production

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. Most developers took one look and backed away slowly. Trevor Manz decided that barrier did not need to exist. His idea was simple: give Python users just enough JavaScript to unlock the web’s interactivity, without dragging along the rest of the web ecosystem. That idea became anywidget, and it is quickly becoming the quiet connective tissue of modern interactive computing. Today we dig into how it works, why it has taken off, and how it might change the way we explore data.

Episode sponsors

Seer: AI Debugging, Code talkpython26

PyCharm, code STRONGER PYTHON

Talk Python Courses

Links from the show
Trevor on GitHub: github.com

anywidget GitHub: github.com

Trevor's SciPy 2024 Talk: www.youtube.com

Marimo GitHub: github.com

Myst (Markdown docs): mystmd.org

Altair: altair-viz.github.io

DuckDB: duckdb.org

Mosaic: uwdata.github.io

ipywidgets: ipywidgets.readthedocs.io

Tension between Web and Data Sci Graphic: blobs.talkpython.fm

Quak: github.com

Walk through building a widget: anywidget.dev

Widget Gallery: anywidget.dev

Video: How do I anywidget?: www.youtube.com

PyCharm + PSF Fundraiser: pycharm-psf-2025 code STRONGER PYTHON

Watch this episode on YouTube: youtube.com

Episode #530 deep-dive: talkpython.fm/530

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#530: anywidget: Jupyter Widgets made easy

A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-night itch to make something work. This week, David Kopec joins me to talk about rebuilding computer science for exactly those folks, the ones who learned to program first and are now ready to understand the deeper ideas that power the tools they use every day.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

NordStellar

Talk Python Courses

Links from the show
David Kopec: davekopec.com

Classic Computer Science Book: amazon.com

Computer Science from Scratch Book: computersciencefromscratch.com

Computer Science from Scratch at NoStartch (CSFS30 for 30% off): nostarch.com

Watch this episode on YouTube: youtube.com

Episode #529 deep-dive: talkpython.fm/529

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#529: Computer Science from Scratch

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused endpoints, and good monitoring. We’ll dig into patterns for wrapping these calls, caching and inspecting responses, and deciding where an LLM API actually earns its keep in your architecture.

Episode sponsors

Seer: AI Debugging, Code talkpython26

NordStellar

Talk Python Courses

Links from the show
Vincent on X: @fishnets88

Vincent on Mastodon: @koaning

LLM Building Blocks for Python Co-urse: training.talkpython.fm

Top Talk Python Episodes of 2024: talkpython.fm

LLM Usage - Datasette: llm.datasette.io

DiskCache - Disk Backed Cache (Documentation): grantjenks.com

smartfunc - Turn docstrings into LLM-functions: github.com

Ollama: ollama.com

LM Studio - Local AI: lmstudio.ai

marimo - A Next-Generation Python Notebook: marimo.io

Pydantic: pydantic.dev

Instructor - Complex Schemas & Validation (Python): python.useinstructor.com

Diving into PydanticAI with marimo: youtube.com

Cline - AI Coding Agent: cline.bot

OpenRouter - The Unified Interface For LLMs: openrouter.ai

Leafcloud: leaf.cloud

OpenAI looks for its "Google Chrome" moment with new Atlas web browser: arstechnica.com

Watch this episode on YouTube: youtube.com

Episode #528 deep-dive: talkpython.fm/528

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

#528: Python apps with LLM building blocks

See the full show notes for this episode on the website at talkpython.fm/514

#514: Python Language Summit 2025

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