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Medscape

This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

This Week in Cardiology

The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I What do risk scores mean for individuals? Or perhaps a better question: Is a first MI preventable?
 
 Limitations of Screening in Predicting First MI https://www.jacc.org/doi/10.1016/j.jacadv.2025.102361 Sudden Death Due to Cardiac Arrhythmias https://www.nejm.org/doi/abs/10.1056/NEJMra000650 UMC Amsterdam group (EHJ) https://academic.oup.com/eurheartj/article/46/38/3762/8181058 
II CELEBRATE Trial
 
 CELEBRATE Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268 
III SURPASS CVOT Trial Published
 
Aug 01, 2025 This Week in Cardiology Podcast
 
 https://www.medscape.com/viewarticle/1002781
 
 SURPASS-CVOT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2505928 REWIND Trial 10.1016/S0140-6736(19)31149-3 External Link 
IV FDA Pulls Andexanet Alfa From the Market
 
 ANNEXA 4 https://www.nejm.org/doi/10.1056/NEJMoa1814051 ANNEXA I https://www.nejm.org/doi/full/10.1056/NEJMoa2313040 Richard Buka Tweet https://x.com/richardbuka/status/2001045834050216327?s=20 
V Mandrola's Top Cardiovascular Stories of 2025
 
 https://www.medscape.com/viewarticle/mandrolas-top-10-cardiovascular-stories-2025-2025a1000yuh
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Dec 19 2025 This Week in Cardiology

An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I AV Block After TAVR
 
Heart Blocks During vs After TAVR Show Distinct Patterns
 
 https://www.medscape.com/viewarticle/heart-blocks-during-vs-after-tavr-show-distinct-patterns-2025a1000ypp
 
 Mechanisms Underlying Alterations in Cardiac Conduction After TAVR https://jamanetwork.com/journals/jamacardiology/fullarticle/2842748 
II Related PSA Announcement to My Structural Colleagues
 
III Revascularization Strategies in Women with Severe Chronic CAD
 
Women With Chronic Severe CAD Fare Better With CABG vs PCI
 
 https://www.medscape.com/viewarticle/women-chronic-severe-cad-fare-better-cabg-vs-pci-2025a1000ygd
 
 PCI vs CABG in Women With Chronic CAD https://doi.org/10.1093/eurheartj/ehaf806 PCI vs CABG - Meta-Analysis of 4 RCTs https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02334-5/abstract CABG vs Drug-Eluting Stent Implantation for CAD - Meta-Analysis https://www.jacc.org/doi/10.1016/j.jcin.2016.10.008 RECHARGE trial https://therechargetrial.com/ 
IV A CTO PCI RCT – But don't get your hopes up
 
 Early vs Late-Staged PCI After Subintimal Tracking and Re-entry for CTO https://doi.org/10.1016/j.jacc.2025.09.1598 DECISION CTO trial https://pubmed.ncbi.nlm.nih.gov/30813758/ National Inpatient Sample Database PCI CTO Associated With Higher Mortality https://pubmed.ncbi.nlm.nih.gov/37356643/ 
V Mandrola's Top 10 Stories
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Dec 12 2025 This Week in Cardiology

Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed by John Mandrola, MD, on this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Less is More: TARGET-FIRST
 
 TARGET-FIRST Trial https://www.nejm.org/doi/10.1056/NEJMoa2508808 STOPDAPT-2 ACS Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2789701 
II A Negative Trial That Is Actually Positive
 
 The RETREAT-FRAIL Study https://www.nejm.org/doi/full/10.1056/NEJMoa2508157 
III Major Bleeding With Aspirin vs Apixaban
 
 Subanalysis of ARTESiA https://jamanetwork.com/journals/jamacardiology/fullarticle/2841075 ARTESiA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2310234 AVERROES Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1007432 
IV High Value Interventions – The AED
 
 Experts Call for AED Placement on All Commercial Aircraft https://www.medscape.com/viewarticle/experts-call-aed-placement-all-commercial-aircraft-2025a1000xzf In-Flight Sudden Cardiac Arrest and AED Use 10.1016/j.cjca.2025.10.010 External Link 
V Factor XI Inhibitors – OCEANIC STROKE trial
 
 Bayer Press Release on Asundexian https://www.bayer.com/en/us/news-stories/oceanic-stroke 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Dec 05 2025 This Week in Cardiology

Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1 
II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published
 
 ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/ CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800 CREST Protocol paper https://pmc.ncbi.nlm.nih.gov/articles/PMC5987521/ 
III Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
 
 PLATO trial https://www.nejm.org/doi/full/10.1056/NEJMoa0904327 Ticagrelor or prasugrel vs clopidogrel in PCI https://eurointervention.pcronline.com/article/ticagrelor-or-prasugrel-versus-clopidogrel-in-patients-undergoing-percutaneous-coronary-intervention-for-chronic-coronary-syndromes ISAR-REACT 5 trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973 
IV Another Coffee and AF study
 
Can Coffee Cut the Risk for Atrial Fibrillation?
 
 https://www.medscape.com/viewarticle/can-coffee-cut-risk-atrial-fibrillation-2025a1000w11
 
A Coffee a Day to Keep the AFib Away? The DECAF Trial Discussed https://www.medscape.com/viewarticle/coffee-day-keep-afib-away-decaf-trial-discussed-2025a1000v5z
 
 DECAF trial https://jamanetwork.com/journals/jama/fullarticle/2841253 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Nov 21 2025 This Week in Cardiology

Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
Why I Believe Fish Oil's Big CV Benefit in Dialysis Patients https://www.medscape.com/viewarticle/why-i-believe-fish-oils-big-cv-benefit-dialysis-patients-2025a1000uzg
 
 PISCES trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513032 
II PCSK9 Inhibitor News
 
In Global Trial, PCSK9 Inhibitor Provides Major Protection Against First CV Event https://www.medscape.com/viewarticle/global-trial-pcsk9-inhibitor-provides-major-protection-2025a1000uzp
 
 VESALIUS-CV trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428 ODYSSEY trial https://www.nejm.org/doi/full/10.1056/NEJMoa1801174 FOURIER https://www.nejm.org/doi/full/10.1056/NEJMoa1615664 Anish Koka Tweet on LDL-lowering https://x.com/anish_koka/status/1987280506937909326?s=20 
III Beta-Blockers After MI and John Cleland
 
 Beta-Blockers after MI with normal EF https://www.nejm.org/doi/full/10.1056/NEJMoa2512686 REBOOT-CNIC trial https://www.nejm.org/doi/full/10.1056/NEJMoa2504735 REDUCE AMI trial https://academic.oup.com/ehjcvp/article/9/2/192/6895544?login=false ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204 CAPITAL RCT trial https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347 Beta-Blockers after MI with mildly reduced EF https://pubmed.ncbi.nlm.nih.gov/40897190/ John Cleland Clinical Outlook https://www.nature.com/articles/s41569-025-01228-w 
IV Left Atrial Appendage Closure – The CLOSURE-AF trial
 
Percutaneous LAAC in AF Falls Short Again in CLOSURE-AF https://www.medscape.com/viewarticle/percutaneous-left-atrial-appendage-closure-af-falls-short-2025a1000uzu
 
 Prague-17 Trial • 
https://www.jacc.org/doi/10.1016/j.jacc.2020.04.067 OPTION trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2408308 
V Oral AC after AF ablation – the OCEAN Trial
 
Anticoagulation After AF Ablation: The OCEAN Trial Still Leaves Questions https://www.medscape.com/viewarticle/anticoagulation-after-af-ablation-ocean-trial-still-leaves-2025a1000v4t
 
 OCEAN Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2509688 ALONE-AF trial • 
https://jamanetwork.com/journals/jama/fullarticle/2838294 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Nov 14 2025 This Week in Cardiology

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 Meta-analysis of MI as a surrogate • 
https://pubmed.ncbi.nlm.nih.gov/34694318/ Compare Acute Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa1701067 DANAMI-3–PRIMULTI • 
10.1016/S0140-6736(15)60648-1 External Link CULPRIT-SHOCK • 
https://www.nejm.org/doi/full/10.1056/NEJMoa1710261 • 
 
II Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST
 
 PISCES Trial • 
www.nejm.org/doi/full/10.1056/NEJMoa2513032 REDUCE-IT Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa1812792 STRENGTH Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2773120 FISH trial • 
https://jamanetwork.com/journals/jama/fullarticle/1150094 
III Obesity Agents
 
 White House announces deal with Lilly and Novo on GLP-1 drugs • 
https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/ 
Amylin Agonists
 
 Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial 
 https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf
 
 Eloralintide Phase 2 Study • 
https://doi.org/10.1016/S0140-6736(25)02155-5 
GLP-1 Comparisons
 
 SURMOUNT-5 Trial • 
https://www.nejm.org/doi/10.1056/NEJMoa2416394 Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction • 
https://doi.org/10.1093/ehjopen/oeaf117 
IV A Problematic Trial in Stroke Care
 
 LAMP trial • 
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370 
V AHA Preview
 
AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Nov 07, 2025 This Week in Cardiology

Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Stable CAD Complete vs culprit-only revascularization at time of STEMI
 
 iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918 PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520 COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149 PCI Revascularization Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051 CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261 How a Meta-Analysis Can Mislead https://www.sensible-med.com/p/how-a-meta-analysis-can-misleadthe 
 
 
II SEVERE Aortic Senosis
 
7-Year PARTNER 3 Results – TAVI vs SAVR
 
 7-year results PARTNER 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2509766 PARTNER 3 at 1 year https://www.nejm.org/doi/10.1056/NEJMoa1814052 PARTNER 3 at 5 years https://www.nejm.org/doi/10.1056/NEJMoa2307447 
III Functional vs Anatomic Assessment in Suspected CAD
 
 10-year follow-up of PROMISE trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2838118 PROMISE Trial https://www.nejm.org/doi/10.1056/NEJMoa1415516 CCTA vs Functional Stress Test – Meta-Analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243 
IV ARREST AF 
 
 ARREST AF trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Oct 31 2025 This Week in Cardiology

The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Is the PREVENT Calculator Best for Determining CVD Risk? Insights From a Post Hoc Analysis of SPRINT Trial
 
 https://www.medscape.com/viewarticle/prevent-calculator-best-determining-cvd-risk-insights-post-2025a1000svo
 
 PREVENT Calculator https://doi.org/10.1016/j.jacc.2025.07.037 SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939 
II GLP-1 Mechanism of Action in CV Disease
 
 Analysis of SELECT Trial • 
10.1016/S0140-6736(25)01375-3 External Link SELECT trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 
III Statins and CAD Phenotype on CTA and Outcomes
 
 Interactions Between Statin Use, CAD Phenotypes on CTA https://www.jacc.org/doi/10.1016/j.jcmg.2025.05.018 Statin Use for Primary Prevention of CVD • 
https://jamanetwork.com/journals/jama/fullarticle/2795522 
IV HHF Endpoints in Heart Failure Trials
 
 The Problem with Hospitalization Endpoints in HF Trials • 
https://onlinelibrary.wiley.com/doi/10.1002/ejhf.70070 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Oct 24 2025 This Week in Cardiology

Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 Trends Study • 
https://www.heartrhythmjournal.com/article/S1547-5271(11)00496-6/fulltext 
II Another knock against the Antiplatelet/Anticoagulation combination
 
"Antiplatelet Plus Oral Anticoagulant Lowers Stroke, Raises Bleeding Risk" https://www.medscape.com/viewarticle/antiplatelet-plus-oral-anticoagulant-lowers-stroke-raises-2025a1000re0
 
 ATIS-NVAF Trial • 
https://jamanetwork.com/journals/jamaneurology/fullarticle/2839511 AQUATIC trial • 
https://www.nejm.org/doi/abs/10.1056/NEJMoa2507532 
III Polypill for HFrEF
 
 A Multilevel Polypill for Patients With HFrEF • 
https://www.jacc.org/doi/10.1016/j.jacadv.2025.102195 
IV The Physical Exam of the Future
 
 Point-of-Care Ultrasound • 
https://doi.org/10.1016/j.jchf.2025.102707 
V More on Underpowered Trials – GA vs Moderate Sedation in IV stroke
 
 SEGA Trial • 
https://jamanetwork.com/journals/jamaneurology/fullarticle/2839838 Bayesian Analyses of CV Trials • 
https://doi.org/10.1016/j.cjca.2021.03.014 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Oct 17 2025 This Week in Cardiology

GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I. Listener Feedback
 
HYPERION trial https://www.nejm.org/doi/10.1056/NEJMoa2508170
 
ZENITH trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160
 
II GLP1 Use in HFrEF
 
Effects of GLP-1s in Patients With HFrEF https://doi.org/10.1016/j.jchf.2025.102573
 
FIGHT Study https://jamanetwork.com/journals/jama/fullarticle/2540402
 
FIGHT Study Post-hoc Analysis https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14862
 
Substudy of EXSCEL Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041659
 
III LA Posterior Wall Isolation Saga
 
Failure of PW Wall Isolation by PFA with Epicardial Mapping https://doi.org/10.1016/j.jacep.2025.08.017
 
IV Peridevice Leaks After LAAO
 
IMPRESSION LAAC Study https://doi.org/10.1016/j.jacep.2025.08.014
 
V Post Cardiac Surgery AF
 
Monitoring of New-Onset AF After CABG https://jamanetwork.com/journals/jama/fullarticle/2839710
 
PACES trial https://clinicaltrials.gov/study/NCT04045665
 
VI TEE vs ICE Before AF ablation
 
ICE vs TEE Study https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Oct 10 2025 This Week in Cardiology

The COVID19 crisis—heroes, viral spread, betrayals, and intolerance of ideas—are discussed by John Mandrola, MD in this week's podcast.

Apr 3, 2020 This Week in Cardiology Podcast

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