The Truth About Hormone Therapy | Office Hours (EP 135)

In this solo episode of the Bendy Bodies Podcast, Dr. Linda Bluestein dives deep into the complex world of hormones, menopause, and connective tissue disorders. She explores how estrogen, progesterone, and testosterone impact joint health, the benefits and risks of hormone replacement therapy (HRT), and why menopause can worsen EDS symptoms. Dr. Bluestein also breaks down gender-affirming hormone therapy, the role of mast cells in hormonal responses, and why some testosterone clinics may not have your best interests at heart. Whether you're considering HRT, navigating menopause with hypermobility, or wondering how hormones influence mast cells, this episode is packed with practical advice and science-backed insights.

Takeaways: Hormones Affect Connective Tissue & Joint Stability – Estrogen, testosterone, and progesterone all influence collagen production, ligament strength, and tissue elasticity, which is why hormonal changes impact pain and mobility. Menopause Can Worsen EDS Symptoms – The decline in estrogen post-menopause contributes to joint pain, fatigue, and increased injury risk, making HRT a potential tool for symptom management. Testosterone Therapy Has Benefits & Risks – While testosterone can improve muscle mass, bone density, and fatigue, it must be monitored carefully to avoid cardiovascular risks, clotting issues, and hormone imbalances. Be Cautious with Hormone Clinics – Some online or walk-in testosterone clinics prioritize sales over patient health, so always ensure proper lab testing and medical oversight before starting HRT. Mast Cells Respond to Hormonal Changes – Hormones like estrogen and progesterone can trigger mast cell activation, impacting inflammation, pain, and allergic responses—especially in conditions like MCAS and POTS.

Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/.

Find the transcript for this episode here.

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